Urea → HCID 178470753, 화합물

반응식

ClC1N=C(Cl)C2CCN(CC3C=CC(OC)=CC=3)C=2N=1.[CH:21]([C:33]([O:35]CC)=O)([C:28]([O:30]CC)=O)[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24].[NH2:38][C:39]([NH2:41])=[O:40]>>[OH:40][C:39]1[N:41]=[C:28]([OH:30])[C:21]([CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[C:33]([OH:35])[N:38]=1

참가 물질

반응물 3

HCID 1176Urea

HCID 81961Triethyl ethane-1,1,2-tricarboxylate

HCID 866996702,4-dichloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine

생성물 1

HCID 178470753HCID 178470753, 화합물수율 52.4%

실험 절차

According to General Protocol I, 2,4-dichloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine was prepared from triethyl ethane-1,1,2-tricarboxylate (10 g, 41 mmol) and urea (2.44 g, 41 mmol), and isolated as a pale-yellow solid (4.6 g, yield 35%).

출처 및 근거

ORD 기록: ord-871773f941e34ba48642bb99c940ecc2
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09428508B2

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