(S)-1,1-dibenzyl 2-ethyl propane-1,1,2-tricarboxylate → (S)-2-(1-ethoxy-1-oxopropan-2-yl)malonic acid

HRID 1487174노트

반응식

HRID 1487174 반응식
[CH:1]([C:19]([O:21]CC1C=CC=CC=1)=[O:20])([C:9]([O:11]CC1C=CC=CC=1)=[O:10])[C@@H:2]([C:4]([O:6][CH2:7][CH3:8])=[O:5])[CH3:3]>CO.[Pd]>[CH2:7]([O:6][C:4](=[O:5])[C@H:2]([CH:1]([C:19]([OH:21])=[O:20])[C:9]([OH:11])=[O:10])[CH3:3])[CH3:8]

참가 물질

4

반응물 1

HCID 86699671(S)-1,1-dibenzyl 2-ethyl propane-1,1,2-tricarboxylate

생성물 1

HCID 86699672(S)-2-(1-ethoxy-1-oxopropan-2-yl)malonic acid수율 83%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To the solution of (S)-1,1-dibenzyl 2-ethyl propane-1,1,2-tricarboxylate (23 g, 0.06 mol) in methanol (500 mL) was added palladium on carbon (10%, 2 g), and then the mixture was stirred under an atmosphere of hydrogen at room temperature overnight. The catalyst was filtrated and the filtrate was concentrated under reduced pressure to afford the crude product (S)-2-(1-ethoxy-1-oxopropan-2-yl)malonic acid, which was purified by silica gel chromatography (10 g, yield 83%).

후처리

  1. filtrationThe catalyst was filtrated
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f00957924cca487ab4b4d6a261d6ac4a
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428508B2

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