Dichloromethane → HCID 86699684, 화합물

HRID 1487192

반응식

HRID 1487192 반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]([N+:13]([O-:15])=[O:14])=[C:6]([CH:8]2[O:12][CH2:11][CH2:10][O:9]2)[CH:7]=1.ClCCl.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[O:9]1[CH2:10][CH2:11][O:12][CH:8]1[C:6]1[CH:7]=[C:2]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[CH:3]=[CH:4][C:5]=1[N+:13]([O-:15])=[O:14]

참가 물질

4

반응물 3

HCID 6344DichloromethaneHCID 8083MorpholineHCID 2673852-(5-Chloro-2-nitrophenyl)-1,3-dioxolane

생성물 1

HCID 86699684HCID 86699684, 화합물수율 97.1%

실험 절차

2-(5-Chloro-2-nitrophenyl)-1,3-dioxolane (13.4 g, 58.4 mmol) was dissolved in morpholine (150 mL). The mixture was then heated to reflux for 16 hours. Cooling to room temperature, dichloromethane was added. The organic phase was washed with water, dried over anhydrous sodium sulfate, evaporated and purified by silica gel chromatography to afford the product 4-(3-(1,3-dioxolan-2-yl)-4-nitrophenyl)morpholine (15.9 g, yield 97.1%).

후처리

  1. temperatureThe mixture was then heated
  2. temperatureto reflux for 16 hours
  3. washThe organic phase was washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customevaporated
  6. custompurified by silica gel chromatography

출처 및 근거

ORD 기록
ord-4a084a21f93a422d9e51761a639bc4a8
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428508B2

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