Ammonia → 3-Amino-6-iodopyrazine-2-carboxamide

HRID 1487354

반응식

HRID 1487354 반응식
[NH3:1].[NH2:2][C:3]1[C:4]([C:10]([O:12]C)=O)=[N:5][C:6]([I:9])=[CH:7][N:8]=1>O.CO>[NH2:2][C:3]1[C:4]([C:10]([NH2:1])=[O:12])=[N:5][C:6]([I:9])=[CH:7][N:8]=1

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 11087124Methyl 3-amino-6-iodopyrazine-2-carboxylate

생성물 1

HCID 468639523-Amino-6-iodopyrazine-2-carboxamide수율 88%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
25 °C

실험 절차

30 ml of ammonia in water is added under magnetic stirring to 15 g (53.8 mmol) of a solution of methyl 3-amino-6-iodopyrazine-2-carboxylate in 150 ml of methanol. The reaction medium is stirred at 25° C. for 48 hours. After evaporation of the solvents, the precipitate obtained is filtered, rinsed with water and then dried at 50° C. to yield 12.50 g of 3-amino-6-iodopyrazine-2-carboxamide (88%) in the form of a beige solid.

후처리

  1. customAfter evaporation of the solvents
  2. customthe precipitate obtained
  3. filtrationis filtered
  4. washrinsed with water
  5. customdried at 50° C.

출처 및 근거

ORD 기록
ord-bf3ff40e2e6f484f89bba172ad18e87e
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428510B2

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