Cyclohexane → HCID 178503531, 화합물

HRID 1487360노트

반응식

HRID 1487360 반응식
[C:1]([C:3]1[C:4]([S:13][CH3:14])=[N:5][C:6]([OH:12])=[C:7]([CH:11]=1)C(O)=O)#[N:2].C1CCCCC1>C1(OC2C=CC=CC=2)C=CC=CC=1>[OH:12][C:6]1[CH:7]=[CH:11][C:3]([C:1]#[N:2])=[C:4]([S:13][CH3:14])[N:5]=1

참가 물질

4

반응물 2

HCID 8078CyclohexaneHCID 178503561HCID 178503561, 화합물

생성물 1

HCID 178503531HCID 178503531, 화합물수율 60.6%

시약·촉매·용매 1

HCID 7583Diphenyl Ether용매

실험 절차

A solution of 6 g (28.5 mmol) of 5-cyano-2-hydroxy-6-(methylthio)nicotinic acid in 35 ml of diphenyl ether is stirred at 250° C. for 4 hours. After returning to room temperature, 100 ml of cyclohexane is added and the reaction medium is triturated for 30 minutes. The solid formed is filtered, rinsed thoroughly with cyclohexane and then dried under vacuum to yield 2.87 g (60%) of 6-hydroxy-2-(methylthio)nicotinonitrile in the form of a brown powder.

후처리

  1. customAfter returning to room temperature
  2. customthe reaction medium is triturated for 30 minutes
  3. customThe solid formed
  4. filtrationis filtered
  5. washrinsed thoroughly with cyclohexane
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-39754df6f5074d1c8016097b6832d611
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428510B2

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