Acetone → (4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine

반응식

[NH2:1][C@H:2]([CH2:12][F:13])[C@@H:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)[OH:4].[CH3:14][C:15]([CH3:17])=O>>[F:13][CH2:12][C@@H:2]1[C@@H:3]([C:5]2[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=2)[O:4][C:15]([CH3:17])([CH3:14])[NH:1]1

참가 물질

반응물 2

HCID 180Acetone

HCID 45257860(2S,1R)-2-Amino-3-fluoro-1-(4-iodo-phenyl)-propan-1-ol

생성물 1

HCID 86695412(4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine

실험 절차

Acetone (150 mL) is added to commercially available (1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol (15.0 g, 50.8 mmol). After stirring overnight at room temperature the solvent is removed under reduced pressure to give the title compound (17.6 g): m/z (CI) M+H 335.

후처리

customis removed under reduced pressure

출처 및 근거

ORD 기록: ord-b18cce1cc27743ea90a58dda2ca16859
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09428528B2

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