Sodium Methoxide → HCID 81429573, 화합물

HRID 1487869노트

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HRID 1487869 반응식
Br[CH2:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][C:4]=1[I:13].[CH3:14][O-:15].[Na+]>CO>[I:13][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:3]=1[CH2:2][O:15][CH3:14])[C:7]([O:9][CH3:10])=[O:8]

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 57446309Methyl 4-(bromomethyl)-3-iodobenzoate2회

생성물 1

HCID 81429573HCID 81429573, 화합물수율 77%

시약·촉매·용매 1

HCID 887Methanol용매

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온도
50 °C

실험 절차

Into a 250-mL round-bottom flask, was placed a mixture of methyl 4-(bromomethyl)-3-iodobenzoate (compound 20.1, 3.0 g, 8.5 mmol) and sodium methoxide (1.8 g, 33 mmol) in methanol (100 mL). The resulting solution was stirred for 2 h at 50° C., then cooled to room temperature and concentrated under reduced pressure. The residue was diluted with ethyl acetate (50 mL) and the solids were filtered off. The filtrate was concentrated under reduced pressure to yield 2.0 g (77%) of the title compound as a yellow solid.

후처리

  1. customInto a 250-mL round-bottom flask, was placed
  2. temperaturecooled to room temperature
  3. concentrationconcentrated under reduced pressure
  4. additionThe residue was diluted with ethyl acetate (50 mL)
  5. filtrationthe solids were filtered off
  6. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-aaaf2cc5db924fa1a5f800055870307d
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

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