4-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1) → 1-Chloro-7-(piperidin-4-yl)imidazo[1,5-a]pyridine hydrochloride

반응식

Cl.N1CCC(C2C=CC(C#N)=CC=2)CC1.[Cl:16][C:17]1[N:18]=[CH:19][N:20]2[CH:25]=[CH:24][C:23]([CH:26]3[CH2:31][CH2:30][N:29](C(OC(C)(C)C)=O)[CH2:28][CH2:27]3)=[CH:22][C:21]=12.C(C1C=CC(C2CCN(C(OC(C)(C)C)=O)CC2)=CC=1)#N>>[ClH:16].[Cl:16][C:17]1[N:18]=[CH:19][N:20]2[CH:25]=[CH:24][C:23]([CH:26]3[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]3)=[CH:22][C:21]=12

참가 물질

반응물 3

HCID 193916184-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1)

HCID 22492960Tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate

HCID 90066730Tert-butyl 4-(1-chloroimidazo[1,5-a]pyridin-7-yl)piperidine-1-carboxylate2회

생성물 1

HCID 1182507381-Chloro-7-(piperidin-4-yl)imidazo[1,5-a]pyridine hydrochloride

실험 절차

The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 1.2, except tert-butyl 4-(1-chloroimidazo[1,5-a]pyridin-7-yl)piperidine-1-carboxylate (compound 68.1) was used in place of tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate (compound 1.1) to yield the title compound as a yellow solid.