Sodium Sulfite → 5-Iodo-2-(methoxymethyl)-1H-imidazole

HRID 1488111노트

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HRID 1488111 반응식
[I:1][C:2]1[N:3]=[C:4]([CH2:8][O:9][CH3:10])[NH:5][C:6]=1I.[O-]S([O-])=O.[Na+].[Na+]>C(O)C.O>[I:1][C:2]1[NH:3][C:4]([CH2:8][O:9][CH3:10])=[N:5][CH:6]=1

참가 물질

5

반응물 2

HCID 24437Sodium SulfiteHCID 667340334,5-diiodo-2-methoxymethyl-1H-imidazole2회

생성물 1

HCID 900305675-Iodo-2-(methoxymethyl)-1H-imidazole수율 76.4%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

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온도
90 °C

실험 절차

Into a 250-mL round-bottom flask, was placed a solution of 4,5-diiodo-2-(methoxymethyl)-1H-imidazole (compound 230.3, 2 g, 5.50 mmol) in ethanol (40 mL). A solution of Na2SO3 (5.9 g, 46.83 mmol) in water (80 mL) was added to the reaction. The reaction mixture was stirred overnight at 90° C. The resulting mixture was concentrated under reduced pressure. The residue was extracted with 3×20 mL of dichloromethane and the organic layers combined and concentrated under reduced pressure. This resulted in 1 g (76%) of the title compounds as yellow oil.

후처리

  1. customInto a 250-mL round-bottom flask, was placed
  2. concentrationThe resulting mixture was concentrated under reduced pressure
  3. extractionThe residue was extracted with 3×20 mL of dichloromethane
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-53452cc1323d4941bc5379e87c6c8d1a
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

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