Ammonium Hydroxide → 5-Iodo-4-methyl-1H-pyrazole-3-carboxamide

HRID 1488164노트

반응식

HRID 1488164 반응식
[I:1][C:2]1[NH:6][N:5]=[C:4]([C:7](OCC)=[O:8])[C:3]=1[CH3:12].[OH-].[NH4+:14]>CO>[I:1][C:2]1[NH:6][N:5]=[C:4]([C:7]([NH2:14])=[O:8])[C:3]=1[CH3:12]

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 90029656Ethyl 3-iodo-4-methyl-1H-pyrazole-5-carboxylate2회

생성물 1

HCID 900301425-Iodo-4-methyl-1H-pyrazole-3-carboxamide수율 89%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
60 °C

실험 절차

Into a 100-mL round-bottom flask, was placed a solution of ethyl 5-iodo-4-methyl-1H-pyrazole-3-carboxylate (compound 258.1, 500 mg, 1.79 mmol) in methanol (5 mL). Then ammonium hydroxide (15 mL, 25% aq.) was added and the resulting solution was stirred overnight at 60° C. The mixture was concentrated under reduced pressure to obtain the title compound as a white solid (400 mg, 89%).

후처리

  1. customInto a 100-mL round-bottom flask, was placed
  2. concentrationThe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-03a19117699a41d9bd57505bb7706270
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

반응 노트

불러오는 중…