Sodium Bicarbonate → HCID 178424697, 화합물

반응식

Br[CH2:2][C:3]1[C:7]([Cl:8])=[C:6]([C:9]2[C:10]([CH3:19])=[CH:11][C:12]([CH3:18])=[C:13]([CH:17]=2)[C:14]([OH:16])=[O:15])[NH:5][N:4]=1.C([O-])(O)=[O:21].[Na+]>>[Cl:8][C:7]1[C:3]([CH2:2][OH:21])=[N:4][NH:5][C:6]=1[C:9]1[C:10]([CH3:19])=[CH:11][C:12]([CH3:18])=[C:13]([CH:17]=1)[C:14]([OH:16])=[O:15]

참가 물질

반응물 2

HCID 516892Sodium Bicarbonate

HCID 178424692HCID 178424692, 화합물2회

생성물 1

HCID 178424697HCID 178424697, 화합물

실험 절차

A mixture of 5-(3-(bromomethyl)-4-chloro-1H-pyrazol-5-yl)-2,4-dimethylbenzoic acid (compound 304.1, 200 mg, 0.58 mmol) and NaHCO3 (0.3 M, 10 mL) was stirred for 30 min at room temperature, then concentrated under reduced pressure. This resulted in 200 ma (crude) of the title compound as a white solid.

후처리

concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록: ord-98563559d3474174ae80268accd53e01
출처 데이터셋: uspto-grants-2016_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09428502B2

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