HCID 178497712, 화합물 → HCID 178425880, 화합물

HRID 1488230노트

반응식

HRID 1488230 반응식
C[O:2][CH:3]1[CH2:8][CH2:7][CH:6]([C:9]2[NH:10][C:11]([C:15]3[CH:16]=[C:17]([CH:22]=[CH:23][C:24]=3[CH3:25])[C:18]([O:20]C)=[O:19])=[C:12]([CH3:14])[N:13]=2)[CH2:5][CH2:4]1>I>[OH:2][CH:3]1[CH2:4][CH2:5][CH:6]([C:9]2[NH:10][C:11]([C:15]3[CH:16]=[C:17]([CH:22]=[CH:23][C:24]=3[CH3:25])[C:18]([OH:20])=[O:19])=[C:12]([CH3:14])[N:13]=2)[CH2:7][CH2:8]1

참가 물질

3

반응물 1

HCID 178497712HCID 178497712, 화합물2회

생성물 1

HCID 178425880HCID 178425880, 화합물

시약·촉매·용매 1

HCID 24841Hydrogen iodide용매

실험 절차

A solution of methyl 3-(2-(4-methoxycyclohexyl)-4-methyl-1H-imidazol-5-yl)-4-methylbenzoate (compound 300.2, 300 mg, 0.88 mmol) in HI (45% in water) (3 mL) was stirred for 2 h at 60° C., then concentrated under reduced pressure. This resulted in 500 mg (crude) of the title compound as brown oil which was used into the next step without further purification.

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c30e486f424e48d7b798adfb98ec2a5b
출처 데이터셋
uspto-grants-2016_08
특허 번호
US09428502B2

반응 노트

불러오는 중…