HCID 10490701, 화합물 → 4-[N-acetyl-N-(4-aminophenyl)amino]-4H-1,2,4-triazole

HRID 1488496노트

반응식

HRID 1488496 반응식
[C:1]([N:4]([N:14]1[CH:18]=[N:17][N:16]=[CH:15]1)[C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[H][H]>[C].[Pd].CO>[C:1]([N:4]([N:14]1[CH:15]=[N:16][N:17]=[CH:18]1)[C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 10490701HCID 10490701, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 106802764-[N-acetyl-N-(4-aminophenyl)amino]-4H-1,2,4-triazole수율 98.8%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

A proper amount of 10% palladium-carbon was added to 15 ml of a methanol solution containing 0.38 g of 4-[N-acetyl-N-(4-nitrophenyl)amino]-4H-1,2,4-triazole and the mixture was subjected to catalytic reduction in the presence of hydrogen gas at room temperature for about 40 minutes. After completion of reaction, the catalyst was removed by filtration, and the resulting filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 0.33 g of 4-[N-acetyl-N-(4-aminophenyl)amino]-4H-1,2,4-triazole from the chloroform/methanol (50/1) eluate.

후처리

  1. customAfter completion of reaction
  2. customthe catalyst was removed by filtration
  3. concentrationthe resulting filtrate was concentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-543030bbd0e1499cb92b902e63405881
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05674886

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