Tetrahydrofuran → Benzoyloxymethyl chloroformate

HRID 1488886노트

반응식

HRID 1488886 반응식
[C:1]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]CCCCCCCCC(O)=O)(=[O:17])CCCCCCCCCCCCCCC.C(Cl)(=O)[C:38]([Cl:40])=[O:39].[O:43]1CCCC1>>[Cl:40][C:38]([O:17][CH2:1][O:18][C:19](=[O:43])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)=[O:39]

참가 물질

4

반응물 3

HCID 8028TetrahydrofuranHCID 65578Oxalyl chlorideHCID 1960674616-Hexadecanoyloxyhexadecanoic acid

생성물 1

HCID 14800986Benzoyloxymethyl chloroformate수율 100%

실험 절차

16-Hexadecanoyloxyhexadecanoic acid (7.73 g, 15.13 mmol) prepared as in (ah) above was dissolved in tetrahydrofuran (140 ml) and oxalyl chloride (4.80 g, 37.83 mmol) was added dropwise. The mixture was stirred at room temperature for 3 days and then the solvent and unreacted oxalyl chloride were evaporated under reduced pressure to give 8.0 g (100%) of the title compound.

후처리

  1. customthe solvent and unreacted oxalyl chloride were evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-921ef381772b40d19bbfa3d65b4afb8e
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05676925

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