Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl alpha-cyclohexyl-alpha-hydroxybenzeneacetate → 4-[Ethyl-[(4-methoxyphenyl)methyl]amino]but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl alpha-cyclohexyl-alpha-hydroxybenzeneacetate | HCID 112035 | — |
| 반응물 | 4-[Ethyl-[(4-methoxyphenyl)methyl]amino]but-2-yn-1-ol | HCID 4248190 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-[Ethyl-[(4-methoxyphenyl)methyl]amino]but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate | HCID 5044225 | — |
반응 단계
reacting a single enantiomer of methyl α-cyclohexyl-α-hydroxybenzeneacetate (IV) with 4-[N-ethyl-(4-methoxyphenyl)methylamino]-2-butyn-1-ol (V) in the presence of a catalytic amount of sodium methoxide in toluene to produce a single enantiomer of 4-[N-ethyl-(4-methoxyphenyl)methylamino]-2-butynyl α-cyclohexyl-α-hydroxybenzeneacetate (VI); and
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05677346 |
| 출처 데이터셋 | uspto-grants-1997_10 |
| ORD ID | ord-06c8c46dc4e34a24b045809eb93a19f6 |
| 출처 메모 | uspto-grants-1997_10 |