m-Chloroperbenzoic acid → 3-(4-phenylthiazol-2-yl)pyridine-N-oxide

HRID 1489237노트

반응식

HRID 1489237 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[S:8][CH:9]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:11]=2)[CH:2]=1.ClC1C=CC=C(C(OO)=[O:26])C=1>ClCCl>[C:12]1([C:10]2[N:11]=[C:7]([C:3]3[CH:2]=[N+:1]([O-:26])[CH:6]=[CH:5][CH:4]=3)[S:8][CH:9]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 7010154-Phenyl-2-(pyridin-3-yl)thiazole

생성물 1

HCID 187071743-(4-phenylthiazol-2-yl)pyridine-N-oxide수율 28.7%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

In 50 ml of dichloromethane was dissolved 1 g of 2-(pyridin-3-yl)-4-phenylthiazole. Thereto was added 900 mg of m-chloroperbenzoic acid at room temperature. The mixture was stirred at the same temperature for 2 hours. The reaction mixture was washed with an aqueous sodium hydrogencarbonate solution and dried. The solvent was removed by distillation. The residue was recrystallized from ethyl acetate to obtain 306 mg of 3-(4-phenylthiazol-2-yl)pyridine-N-oxide as a brown powder.

후처리

  1. washThe reaction mixture was washed with an aqueous sodium hydrogencarbonate solution
  2. customdried
  3. customThe solvent was removed by distillation
  4. customThe residue was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-0d4d97c01f5c4160a41867accee9bad3
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05677319

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