3,4-Diethoxybenzene-1-carbothioamide → 2-(3,4-Diethoxyphenyl)-4-(5-carboxy-3-furyl)thiazole

HRID 1489283노트

반응식

HRID 1489283 반응식
C([O:3][C:4]([C:6]1[O:10][CH:9]=[C:8]([C:11](=O)[CH2:12]Br)[CH:7]=1)=[O:5])C.[CH2:15]([O:17][C:18]1[CH:19]=[C:20]([CH:24]=[CH:25][C:26]=1[O:27][CH2:28][CH3:29])[C:21]([NH2:23])=[S:22])[CH3:16]>>[CH2:15]([O:17][C:18]1[CH:19]=[C:20]([C:21]2[S:22][CH:12]=[C:11]([C:8]3[CH:7]=[C:6]([C:4]([OH:3])=[O:5])[O:10][CH:9]=3)[N:23]=2)[CH:24]=[CH:25][C:26]=1[O:27][CH2:28][CH3:29])[CH3:16]

참가 물질

3

반응물 2

HCID 77452503,4-Diethoxybenzene-1-carbothioamideHCID 187073605-Ethoxycarbonyl-3-(alpha-bromoacetyl)furan

생성물 1

HCID 187073642-(3,4-Diethoxyphenyl)-4-(5-carboxy-3-furyl)thiazole

실험 절차

5-Ethoxycarbonyl-3-(α-bromoacetyl)furan and 3,4- diethoxythiobenzamide were subjected to the same reaction as in Example 1 and then to the same hydrolysis as in Example 147 to obtain 2-(3,4-diethoxyphenyl)-4-(5-carboxy-3-furyl)thiazole.

후처리

  1. customto the same hydrolysis as in Example 147

출처 및 근거

ORD 기록
ord-13928ea54e4e46b1a3bcb4e6dcc7e4c2
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05677319

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