Thionyl Chloride → 3-(2-Biphenylyl)-2-ethylpropionyl chloride

HRID 1489313

반응식

HRID 1489313 반응식
[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH:8]([CH2:12][CH3:13])[C:9](O)=[O:10].S(Cl)([Cl:22])=O>>[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH:8]([CH2:12][CH3:13])[C:9]([Cl:22])=[O:10]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 215719833-(2-Biphenylyl)-2-ethylpropionic acid

생성물 1

HCID 223402173-(2-Biphenylyl)-2-ethylpropionyl chloride수율 106.3%

실험 절차

To a 100-ml three-necked round flask (equipped with stirrer chip, Dimroth condenser, thermometer and NaOH trap) were introduced 13.3 g (52.4 mmol) of the 3-(2-biphenylyl)-2-ethylpropionic acid and 25.9 ml (355 mmol) of thionyl chloride, and they were refluxed for 2.5 hours with heating in a nitrogen atmosphere. After the reaction was completed, the unreacted thionyl chloride was distilled off under reduced pressure to obtain 15.2 g of a crude product of yellow orange liquid. This acid chloride was used for the next reaction without further purification. The properties of the product thus obtained are described below.

후처리

  1. customTo a 100-ml three-necked round flask (equipped with stirrer chip, Dimroth condenser
  2. temperaturewere refluxed for 2.5 hours
  3. temperaturewith heating in a nitrogen atmosphere
  4. distillationthe unreacted thionyl chloride was distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-ca9642abf1f94eaca83a79f5b40c43cb
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05677408

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