Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (S)-N-[1-(amino-imino-methyl)-piperidin-3-ylmethyl]-benzamide (R)-hydroxy-phenylacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methanesulfonic acid, aminoimino- | HCID 9877361 | — |
| 반응물 | (R)-N-piperidin-3-ylmethyl-benzamide (R)-hydroxy-phenyl-acetate | HCID 70050196 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | (S)-N-[1-(amino-imino-methyl)-piperidin-3-ylmethyl]-benzamide (R)-hydroxy-phenylacetate | HCID 86748615 | 62.4% |
반응 단계
Bc) 19.3 g of the mandelic acid salt obtained under Bb) are suspended in 193 ml of DMF, treated with 21.7 ml of triethylamine and 7.75 g of formamidinesulfonic acid and stirred at room temperature. The reaction mixture is evaporated and the residue is chromatographed on RP-18 silica gel with a water-acetonitrile gradient. There are isolated 13.4 g of (S)-N-[1-(amino-imino-methyl)-piperidin-3-ylmethyl]-benzamide (R)-hydroxy-phenyl-acetate (1:1), MS (FAB): 218 M-(H2N--CN).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05677448 |
| 출처 데이터셋 | uspto-grants-1997_10 |
| ORD ID | ord-2c73f8d2c19a425893bff09943551c0a |
| 출처 메모 | uspto-grants-1997_10 |