Formaldehyde → Sevoflurane

HRID 1489493

반응식

HRID 1489493 반응식
[FH:1].[CH2:2]=O.[CH:4]([OH:13])([C:9]([F:12])([F:11])[F:10])[C:5]([F:8])([F:7])[F:6]>S(=O)(=O)(O)O>[CH2:2]([F:1])[O:13][CH:4]([C:9]([F:12])([F:11])[F:10])[C:5]([F:8])([F:7])[F:6]

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 135291,1,1,3,3,3-Hexafluoro-2-propanolHCID 14917Hydrofluoric Acid

생성물 1

HCID 5206Sevoflurane수율 87.5%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
65 °C

실험 절차

A 500 ml reactor was charged with 50 ml of 98% sulfuric acid, 100 g (5 mol) of hydrogen fluoride, and 30 g (1 mol) of paraformaldehyde. This reaction mixture was heated to 65° C. Then, 134 g (0.8 mol) of HFIP was added dropwise, over 2 hr. Vapors generated by the reaction were collected using water. With this, 140 g of crude SEVOFLURANE was obtained.

후처리

  1. customwere collected

출처 및 근거

ORD 기록
ord-c5ed7c93ae5f4696a4833a8f7e611625
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05679576

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