Thionyl Chloride → 3-(2-Fluorocyclopentyloxy)-4-methoxybenzoyl chloride

HRID 1489690

반응식

HRID 1489690 반응식
[F:1][CH:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[O:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:11](O)=[O:12].S(Cl)([Cl:21])=O>C1(C)C=CC=CC=1>[F:1][CH:2]1[CH2:6][CH2:5][CH2:4][CH:3]1[O:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])[C:11]([Cl:21])=[O:12]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 211879463-(2-Fluorocyclopentyloxy)-4-methoxybenzoic acid

생성물 1

HCID 211878913-(2-Fluorocyclopentyloxy)-4-methoxybenzoyl chloride

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
60 °C

실험 절차

A suspension of 3-(2-fluorocyclopentyloxy)-4-methoxybenzoic acid (0.48 g) in toluene (20 mL) is treated with thionyl chloride (0.34 g) and then is heated at 60° C. for 3 hours, and cooled and evaporated to give 3-(2-fluorocyclopentyl-oxy)-4-methoxybenzoyl chloride.

후처리

  1. temperaturecooled
  2. customevaporated

출처 및 근거

ORD 기록
ord-56405dc4aaa64040a9448660bb0f3fbb
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05679696

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