Water → 5-chloro-N-(2,2,3,3,4,4,4-heptafluorobutyl)-N-methyl-pentanesulfonamide

HRID 1489835노트

반응식

HRID 1489835 반응식
Cl.[F:2][C:3]([F:14])([C:7]([F:13])([F:12])[C:8]([F:11])([F:10])[F:9])[CH2:4][NH:5][CH3:6].C(N(CC)CC)C.[Cl:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][S:28](Cl)(=[O:30])=[O:29].O>C(Cl)Cl>[Cl:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][S:28]([N:5]([CH2:4][C:3]([F:14])([F:2])[C:7]([F:12])([F:13])[C:8]([F:9])([F:10])[F:11])[CH3:6])(=[O:30])=[O:29]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 12589202HCID 12589202, 화합물HCID 19711030N-(2,2,3,3,4,4,4-heptafluorobutyl)-N-methylamine hydrochloride

생성물 1

HCID 197110325-chloro-N-(2,2,3,3,4,4,4-heptafluorobutyl)-N-methyl-pentanesulfonamide수율 101.5%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

500 mg of N-(2,2,3,3,4,4,4-heptafluorobutyl)-N- methylamine hydrochloride (obtained according to European Patent No. 384,842 Example 75) and then, at 0° to 5° C., 0.55 ml of triethylamine were added to a solution of 200 mg of 5-chloropentane sulfonyl chloride in 5 ml of methylene chloride, and the mixture was stirred at ambient temperature for 2 hours. Water was added and extraction was carried out with methylene chloride. The extracts were washed with water, then with a saturated aqueous solution of sodium chloride, dried and evaporated to dryness under reduced pressure to obtain 378 mg of the expected product.

후처리

  1. extractionextraction
  2. washThe extracts were washed with water
  3. dry with materialwith a saturated aqueous solution of sodium chloride, dried
  4. customevaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-7b4eeda8117a421a98acc9e86f9a5dba
출처 데이터셋
uspto-grants-1997_10
특허 번호
US05679788

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