Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,4-Dibromobutane → Diethyl tetrahydropyridazine-1,2-dicarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,4-Dibromobutane | HCID 8056 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1,2-Hydrazinedicarboxylic acid, 1,2-diethyl ester | HCID 77758 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Diethyl tetrahydropyridazine-1,2-dicarboxylate | HCID 281963 | 69.4% |
반응 단계
1,4-Dibromobutane (81.4 mL, 0.682 mol) is added over 1 hour to a mixture of 1,2-dicarbethoxyhydrazine (100 g, 0.568 mol) and potassium carbonate (158 g, 1.14 mol) in acetonitrile (600 mL). The resultant reaction mixture is refluxed for 6 hours, cooled to room temperature, and filtered. The filtrate is concentrated in vacuo to obtain a yellow liquid which is distilled under reduced pressure to give the title product as a colorless liquid (90.8 g, bp 115°-120° C. at 0.9 mm Hg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05679791 |
| 출처 데이터셋 | uspto-grants-1997_10 |
| ORD ID | ord-f76d9f548038467ca151cbcb084816ed |
| 출처 메모 | uspto-grants-1997_10 |