Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Raloxifene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Raloxifene Hydrochloride | HCID 54900 | — |
| 반응물 | Linolenoyl chloride | HCID 5702742 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Raloxifene | HCID 5035 | — |
반응 단계
This derivative was prepared in a manner similar to Example 1, using 2.6 g (0.005 mol) of Raloxifene HCl, 2 g (0.02 mol) of triethylamine, 20 mg of DMAP, and 3.2 g (0.01 mol) of linolenoyl chloride in 250 mL of THF. The final product was chromatographed on a silica gel column eluted with EtOAc-hexane (8:2). This yielded 3.21 g of the title compound as clear oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05726168 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-5c5c39356f4c47209692dae46b65a52e |
| 출처 메모 | uspto-grants-1998_03 |