Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 6-(4-(2-(N-Methyl-4-chlorobenzenesulphonylamino)ethyl)phenyl)-6-(3-pyridyl)hex-5-enoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | 6-(4-(2-(4-Chlorobenzenesulphonylamino)ethyl)-phenyl)-6-(3-pyridyl)hex-5-enoic acid | HCID 65971 | — |
| 촉매 | Benzyltrimethylammonium chloride | HCID 5963 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | 6-(4-(2-(N-Methyl-4-chlorobenzenesulphonylamino)ethyl)phenyl)-6-(3-pyridyl)hex-5-enoic acid | HCID 54262804 | — |
반응 단계
2.0 g of 6-(4-(2-(4-chlorobenzenesulphonylamino)ethyl)-phenyl)-6-(3-pyridyl)hex-5-enoic acid are stirred overnight in 10 ml of 4N sodium hydroxide solution, 100 ml of methylene chloride, 80 mg of benzyl trimethylammonium chloride and 0.85 g of methyl iodide. Then the organic phase is separated off and the aqueous phase is acidified to pH 5. The product precipitated is separated off and taken up in methylene chloride, dried and evaporated down. Finally, the residue is chromatographed with ethylene chloride/methanol (97:3) over a silica gel column.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05681961 |
| 출처 데이터셋 | uspto-grants-1997_10 |
| ORD ID | ord-5193915b0bde4c429b5f8ef4d1e5471f |
| 출처 메모 | uspto-grants-1997_10 |