5-Chloroindole → 5-chloro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole

HRID 1490413노트

반응식

HRID 1490413 반응식
Clc1ccc2[nH]ccc2c1>C1=CCCC=CCC1.C1=CCCC=CCC1.C1CCOC1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC1(C)OBOC1(C)C.[Cl-].[Cl-].[Ir].[Ir]>CC1(C)OB(c2cc(Cl)cc3cc[nH]c23)OC1(C)C

참가 물질

7

반응물 1

HCID 871105-Chloroindole

생성물 1

HCID 461918225-chloro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole수율 64%

시약·촉매·용매 5

HCID 2733548Bis(pinacolato)diborane시약HCID 27347684,4,5,5-Tetramethyl[1,3,2]dioxaborolane시약HCID 42491874,4'-Di-tert-butyl-2,2'-bipyridyl시약HCID 82923Chloro-1,5-cyclooctadiene-iridium(I) dimer촉매HCID 8028Tetrahydrofuran용매

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온도
80 °C

출처 및 근거

ORD 기록
ord-23ce4aa5744d4b52a155df6225c301b4
출처 데이터셋
Borylation dataset from Roche

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