1-Methyl-2,3-dihydro-1H-indole → 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indole
반응식
CN1CCc2ccccc21>B1Oc2ccccc2O1.C1=CC2C=CC1C2.CC(C)(O)C(C)(C)O.CCN(CC)CC.Cc1ccccc1.Fc1c(F)c(F)c(B(c2c(F)c(F)c(F)c(F)c2F)c2c(F)c(F)c(F)c(F)c2F)c(F)c1F>CN1CCc2cc(B3OC(C)(C)C(C)(C)O3)ccc21참가 물질
8
반응물 1
생성물 1
시약·촉매·용매 6
반응 조건
- 온도
- 25 °C
실험 절차
Prepared from 1-methylindoline (1j, 13.5 mg, 0.100 mmol, 1.00 equiv), catBH (24.0 mg, 0.200 mmol, 2.00 equiv), norbornadiene (9.2 mg, 0.10 mmol, 1.00 equiv) and B(C6F5)3 (5.1 mg, 0.010 mmol, 0.10 equiv) according to GP 3. The title compound was purified by flash column chromatography using cyclohexane/EtOAc/Et3N (30/1/1) as eluent to afford 3j (7.5 mg, 30%) as a white solid.
출처 및 근거
- ORD 기록
- ord-a69ae003920743bcb48cb3ac16966ce5
- 출처 데이터셋
- Borylation dataset from Roche
반응 노트
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