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2,6-Dimethoxypyridine → 2,6-Dimethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

HRID 1490565
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HRID 1490565 반응식
COc1cccc(OC)n1>C1=CCCC=CCC1.C1=CCCC=CCC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC1CCCC1.C[OH2+].C[OH2+].[Ir].[Ir].c1ccc(N2B(B3Nc4ccccc4N3c3ccccn3)Nc3ccccc32)nc1>COc1cc(B2OC(C)(C)C(C)(C)O2)cc(OC)n1
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참가 물질

6

반응물 1

HCID 803782,6-Dimethoxypyridine

생성물 1

HCID 467394422,6-Dimethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine수율 69%

시약·촉매·용매 4

HCID 2733548Bis(pinacolato)diborane시약HCID 1223807993-pyridin-2-yl-2-(3-pyridin-2-yl-1H-1,3,2-benzodiazaborol-2-yl)-1H-1,3,2-benzodiazaborole시약HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium촉매

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온도
100 °C

실험 절차

The general procedure A was followed using 2,6-dimethoxypyridine (69.6 mg, 0.5 mmol) and B2pin2 (126.9 mg, 0.5 mmol, 1.0 eq.) as starting material. The resulting mixture was allowed to stir 16 hours at 100 oC. 5x was obtained as white solid (91.5 mg, 69%) after purification by silica gel flash chromatography (Acetone/PE=1:5 v/v). m.p.: 97-99 oC.

출처 및 근거

ORD 기록
ord-1e52b4ddd38c4c05a7343b3e9b602f01
출처 데이터셋
Borylation dataset from Roche
DOI
10.1021/jacs.5b05252

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HCID 138539
Cyclopentyl methyl ether
용매