반응식
CC(=O)Nc1ccccc1Cl>C1=CCCC=CCC1.C1=CCCC=CCC1.C1CCOC1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CCCC[N+](CCCC)(CCCC)CCCC.C[OH2+].C[OH2+].Cc1ccc(-c2ccc(CS(=O)(=O)[O-])cn2)nc1.[Ir].[Ir]>CC(=O)Nc1cc(B2OC(C)(C)C(C)(C)O2)ccc1Cl.CC(=O)Nc1ccc(B2OC(C)(C)C(C)(C)O2)cc1Cl참가 물질
7
반응물 1
생성물 2
시약·촉매·용매 4
반응 조건
- 온도
- 50 °C
실험 절차
Following general procedure F using 2‐chloroacetanilide (42.4 mg, 0.25 mmol), B2pin2 (127 mg, 0.50 mmol), [Ir(COD)OMe]2 (2.5 mg, 0.00375 mmol) and 1a (3.8 mg, 0.0075 mmol) in THF (1.25 mL). The reaction was stirred at 50 °C for 20 hours before cooling and the solvents removed. Analysis of crude 1 H NMR using internalstandard 1,2‐dimethoxyethane showed 1:1.1 meta:para borylation in 74% yield. The crude product was purified by silica gel chromatography (Pet. Ether (40‐60):EtOAc (19:1‐6:4) to give the title compound (as a 1:1.3:0.4 mixture of meta:para:SM ratio, as determined by 1 H NMR) as a colourless oil. NMR yields have been used for all comparisons.
출처 및 근거
- ORD 기록
- ord-364444f55747421995a80216950a4c51
- 출처 데이터셋
- Borylation dataset from Roche
연결된 노트
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