6-Methoxyquinoline-2-carbonitrile → HCID 178487953, 화합물

HRID 1490910

반응식

HRID 1490910 반응식
COc1ccc2nc(C#N)ccc2c1>C1=CCCC=CCC1.C1=CCCC=CCC1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(C)(C)C.C[OH2+].C[OH2+].[Ir].[Ir]>COc1ccc2nc(C#N)cc(B3OC(C)(C)C(C)(C)O3)c2c1

참가 물질

6

반응물 1

HCID 2304816-Methoxyquinoline-2-carbonitrile

생성물 1

HCID 178487953HCID 178487953, 화합물수율 87%

시약·촉매·용매 4

HCID 2733548Bis(pinacolato)diborane시약HCID 42491874,4'-Di-tert-butyl-2,2'-bipyridyl시약HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium촉매HCID 15413tert-Butyl methyl ether용매

반응 조건

온도
25 °C

실험 절차

General procedure B was applied to 6-methoxyquinoline-2-carbonitrile (184 mg, 1.00mmol). The reaction was stirred at room temperature for 48 hours. Upon completion,volatiles were removed under reduced pressure and the remaining residue was purified by silica gel flash-column chromatography with gradient elution of MeOH/DCM from 0.5 -12.5% over 25 column volumes, affording 6-methoxy-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)quinoline-2-carbonitrile as a off-white solid (270 mg, 87%);

출처 및 근거

ORD 기록
ord-5c863801736b4499b0d1a54e4561f8db
출처 데이터셋
Borylation dataset from Roche

연결된 노트

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