2-Methylacetophenone → 1-[2-Methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone

HRID 1490930노트

반응식

HRID 1490930 반응식
CC(=O)c1ccccc1C>C1=CCCC=CCC1.C1=CCCC=CCC1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(C)(C)C.C[OH2+].C[OH2+].[Ir].[Ir]>CC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)ccc1C.CC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1C

참가 물질

7

반응물 1

HCID 113402-Methylacetophenone

생성물 2

HCID 754871961-[2-Methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethanone수율 49%HCID 1299466461-(2-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethan-1-one수율 38%

시약·촉매·용매 4

HCID 2733548Bis(pinacolato)diborane시약HCID 42491874,4'-Di-tert-butyl-2,2'-bipyridyl시약HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium촉매HCID 15413tert-Butyl methyl ether용매

반응 조건

온도
25 °C

실험 절차

General procedure Cwas applied to 1-(2’-methylphenyl)ethanone15f(54mg, 0.4mmol). The reaction mixture was was stirredat room temperature for 16hours giving a conversion of 87%(GC-MS) and 16fand 17fin a 56:44 mixture which also contained unreacted starting material 15f(1H NMRspectrum).

출처 및 근거

ORD 기록
ord-7774858fb93f41f7b91cc112210ae5ae
출처 데이터셋
Borylation dataset from Roche

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