홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Methyl o-toluate → Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

HRID 1490932
노트
인쇄 미리보기

반응식

HRID 1490932 반응식
COC(=O)c1ccccc1C>C1=CCCC=CCC1.C1=CCCC=CCC1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.COC(C)(C)C.C[OH2+].C[OH2+].[Ir].[Ir]>COC(=O)c1cc(B2OC(C)(C)C(C)(C)O2)ccc1C.COC(=O)c1ccc(B2OC(C)(C)C(C)(C)O2)cc1C
참가 물질반응 조건실험 절차출처 및 근거반응 노트

참가 물질

7

반응물 1

HCID 33094Methyl o-toluate

생성물 2

HCID 22930450Methyl 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate수율 27%HCID 24824346Methyl 2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate수율 73%

시약·촉매·용매 4

HCID 2733548Bis(pinacolato)diborane시약HCID 42491874,4'-Di-tert-butyl-2,2'-bipyridyl시약HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium촉매HCID 15413tert-Butyl methyl ether용매

반응 조건

온도
25 °C

실험 절차

General procedure D was applied to methyl 2-methylbenzoate15h(30 mg, 0.2 mmol). The reaction mixture was allowed to stand for 16hoursgiving a conversion of >99%(GC-MS) and 16hand 17hin a 73:27 mixture (1H NMR spectrum).

출처 및 근거

ORD 기록
ord-19c4d9b183614cef9fce523033f6b00a
출처 데이터셋
Borylation dataset from Roche
DOI
10.1039/c2sc20776a

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차출처 및 근거반응 노트