Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1491136생성일: 2026년 10월 26일
1-Chloro-4-(methylthio)benzene → 2-(5-Chloro-2-(methylthio)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
https://huagongshe.com/reaction/1491136
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Chloro-4-(methylthio)benzene | HCID 31243 | — |
| 시약 | Bis(pinacolato)diborane | HCID 2733548 | — |
| 시약 | 2-Pyridin-2-yl-5-[2-[4-(trifluoromethyl)-1,3,2-dioxaborolan-2-yl]phenyl]pyridine | HCID 134956623 | — |
| 촉매 | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| 용매 | P-Xylene | HCID 7809 | — |
| 생성물 | 2-(5-Chloro-2-(methylthio)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 163198006 | 74% |
| 생성물 | HCID 178503174 | HCID 178503174 | 6% |
반응 단계
Ligand 3f: A mixture of ortho- and meta-borylated products (114 mg, 80% yield, ortho/meta + para = 12); ortho-borylated product 4e was obtained by further purification by GPC (70 mg, 49% yield), white solid (mp. 80-82 oC);
출처 및 근거
| DOI | 10.1002/anie.201610041 |
|---|
| 출처 데이터셋 | Borylation dataset from Roche |
|---|
| ORD ID | ord-903f8118d14f42ecaa64e874e6518ce2 |
|---|
| 출처 메모 | Borylation dataset from Roche |
|---|
