N-Boc-4-hydroxyaniline → Tert-butyl (4-hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)carbamate

HRID 1491233노트

반응식

HRID 1491233 반응식
CC(C)(C)OC(=O)Nc1ccc(O)cc1>C1=CCCC=CCC1.C1=CCCC=CCC1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC1(C)OBOC1(C)C.COC(C)(C)C.C[OH2+].C[OH2+].[Ir].[Ir]>CC(C)(C)OC(=O)Nc1ccc(O)cc1B1OC(C)(C)C(C)(C)O1

참가 물질

7

반응물 1

HCID 2756771N-Boc-4-hydroxyaniline

생성물 1

HCID 71742938Tert-butyl (4-hydroxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-YL)phenyl)carbamate수율 78%

시약·촉매·용매 5

HCID 2733548Bis(pinacolato)diborane시약HCID 27347684,4,5,5-Tetramethyl[1,3,2]dioxaborolane시약HCID 42491874,4'-Di-tert-butyl-2,2'-bipyridyl시약HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium촉매HCID 15413tert-Butyl methyl ether용매

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온도
50 °C

출처 및 근거

ORD 기록
ord-1139608af0de453f8fc0d7e140ea28b2
출처 데이터셋
Borylation dataset from Roche

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