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N-Boc-4-chloro-3-fluoroaniline → HCID 130053535, 화합물

HRID 1491240
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HRID 1491240 반응식
CC(C)(C)OC(=O)Nc1ccc(Cl)c(F)c1>C1=CCCC=CCC1.C1=CCCC=CCC1.CC(C)(C)c1ccnc(-c2cc(C(C)(C)C)ccn2)c1.CC1(C)OB(B2OC(C)(C)C(C)(C)O2)OC1(C)C.CC1(C)OBOC1(C)C.COC(C)(C)C.C[OH2+].C[OH2+].[Ir].[Ir]>CC(C)(C)OC(=O)Nc1cc(F)c(Cl)cc1B1OC(C)(C)C(C)(C)O1.CC(C)(C)OC(=O)Nc1ccc(Cl)c(F)c1B1OC(C)(C)C(C)(C)O1
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참가 물질

8

반응물 1

HCID 59652188N-Boc-4-chloro-3-fluoroaniline

생성물 2

HCID 124221708Carbamic acid, N-[4-chloro-3-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, 1,1-dimethylethyl ester수율 16%HCID 130053535HCID 130053535, 화합물수율 52%

시약·촉매·용매 5

HCID 2733548Bis(pinacolato)diborane시약HCID 27347684,4,5,5-Tetramethyl[1,3,2]dioxaborolane시약HCID 42491874,4'-Di-tert-butyl-2,2'-bipyridyl시약HCID 76001521Bis(1,5-cyclooctadiene)dimethoxydiiridium촉매HCID 15413tert-Butyl methyl ether용매

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온도
50 °C

출처 및 근거

ORD 기록
ord-d704933bec314454a9f0b189aec17ed1
출처 데이터셋
Borylation dataset from Roche
DOI
10.1021/ja303443m

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