Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1491495생성일: 2026년 10월 27일
1-Phenylisoquinoline → 1-[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinoline
https://huagongshe.com/reaction/1491495
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Phenylisoquinoline | HCID 137882 | — |
| 시약 | Bis(pinacolato)diborane | HCID 2733548 | — |
| 시약 | 4,4,5,5-Tetramethyl[1,3,2]dioxaborolane | HCID 2734768 | — |
| 시약 | N,N-Dibenzyl-N'-(pyridin-2-ylmethylene)hydrazine | HCID 67601456 | — |
| 촉매 | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinoline | HCID 140786443 | 78% |
반응 단계
Following the general procedure, precipitation from the reaction crude with hexane, trituration and filtration afforded 9n (132 mg, 80 %) as a light brown solid.
출처 및 근거
| DOI | 10.1002/anie.201104544 |
|---|
| 출처 데이터셋 | Borylation dataset from Roche |
|---|
| ORD ID | ord-9cd5a8a6d6f84ea8b68e2222fc75d190 |
|---|
| 출처 메모 | Borylation dataset from Roche |
|---|
