Imidazole → HCID 18953543, 화합물

HRID 1491635노트

반응식

HRID 1491635 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N+:8]([O-:10])=[O:9].[NH:11]1[CH:15]=[CH:14][N:13]=[CH:12]1.C(N(CC)CC)C>O1CCOCC1>[N:11]1([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[N+:8]([O-:10])=[O:9])[CH:15]=[CH:14][N:13]=[CH:12]1

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 8471TriethylamineHCID 27357814-Chloro-3-nitropyridine

생성물 1

HCID 18953543HCID 18953543, 화합물수율 96.4%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

4-Chloro-3-nitropyridine (2.00 g, 12.6 mmol) and imidazole (2.25 g, 33.0 mmol) were dissolved in 10 ml of 1,4-dioxane, and 2 ml of triethylamine was added thereto. followed by reaction at 90° to 100° C. for 1.5 hours. Then, the solvent was removed by distillation under reduced pressure, and the residue was purified by silica gel column chromatography [eluent: dichloromethane:methanol=10:1 (v/v)] to obtain 2.31 g of a yellow liquid (yield: 96.4%).

후처리

  1. customfollowed by reaction at 90° to 100° C. for 1.5 hours
  2. customThen, the solvent was removed by distillation under reduced pressure
  3. customthe residue was purified by silica gel column chromatography [eluent: dichloromethane:methanol=10:1 (v/v)]

출처 및 근거

ORD 기록
ord-63b17d028b914c05af8b2189e6abb7f7
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05371086

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