Amidinothiourea → 4-(6-Aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole

HRID 1491840노트

반응식

HRID 1491840 반응식
Br.C([NH:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([C:13](=O)[CH2:14]Br)[N:8]=1)(=O)C.[NH2:17][C:18](=[N:20][C:21]([NH2:23])=[S:22])[NH2:19]>CO>[NH2:5][CH2:6][C:7]1[N:8]=[C:9]([C:13]2[N:23]=[C:21]([N:20]=[C:18]([NH2:19])[NH2:17])[S:22][CH:14]=2)[CH:10]=[CH:11][CH:12]=1

참가 물질

4

반응물 2

HCID 2724563AmidinothioureaHCID 189538712-(Acetylaminomethyl)-6-bromoacetylpyridine hydrobromide

생성물 1

HCID 103997684-(6-Aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole수율 42.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 2-(acetylaminomethyl)-6-bromoacetyl-pyridine hydrobromide (3.34 g) and diaminomethylenethiourea (1.01 g) in methanol (50 ml) was refluxed for 10 hours with stirring. The resulting precipitate was collected, dissolved in water (50 ml) and the solution was made basic with aqueous potassium carbonate. The separated product was collected and washed with water to give 4-(6-aminomethylpyridin-2-yl)-2-(diaminomethyleneamino)thiazole (0.90 g).

후처리

  1. temperaturewas refluxed for 10 hours
  2. customThe resulting precipitate was collected
  3. dissolutiondissolved in water (50 ml)
  4. customThe separated product was collected
  5. washwashed with water

출처 및 근거

ORD 기록
ord-5cd42c238e234c7aac371864cfa42aca
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05371097

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