4-[(2-Acetylamino-1-iminoethylthio)acetyl]-2-(diaminomethyleneamino)thiazole hydrobromide → 4-(2-Acetylaminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole

HRID 1491863노트

반응식

HRID 1491863 반응식
Br.[C:2]([NH:5][CH2:6][C:7](=[NH:21])[S:8][CH2:9][C:10]([C:12]1[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=1)=O)(=[O:4])[CH3:3]>C(O)C>[C:2]([NH:5][CH2:6][C:7]1[S:8][CH:9]=[C:10]([C:12]2[N:13]=[C:14]([N:17]=[C:18]([NH2:20])[NH2:19])[S:15][CH:16]=2)[N:21]=1)(=[O:4])[CH3:3]

참가 물질

3

반응물 1

HCID 189537784-[(2-Acetylamino-1-iminoethylthio)acetyl]-2-(diaminomethyleneamino)thiazole hydrobromide

생성물 1

HCID 104023264-(2-Acetylaminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole수율 74.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A suspension of 4-[(2-acetylamino-1-iminoethylthio)acetyl]-2-(diaminomethyleneamino)thiazole hydrobromide (11.4 g) in ethanol (100 ml) was refluxed for 2.5 hours. The resulting precipitate was collected by filtration and suspended in water (150 ml). The mixture was alkalized to pH 11 with a saturated aqueous potassium carbonate solution. The resulting precipitate was collected by filtration. Recrystallization from water afforded 4-(2-acetylaminomethylthiazol-4-yl)-2-(diaminomethyleneamino)thiazole (6.36 g).

후처리

  1. temperaturewas refluxed for 2.5 hours
  2. filtrationThe resulting precipitate was collected by filtration
  3. filtrationThe resulting precipitate was collected by filtration
  4. customRecrystallization from water

출처 및 근거

ORD 기록
ord-c3e1993b409540488714a79014ffdfef
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05371097

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