Sulfuryl chloride → (2E)-2-[2-(4-chlorophenoxy)phenyl]-2-methoxyimino-N-methylacetamide

HRID 1491977

반응식

HRID 1491977 반응식
[CH3:1][NH:2][C:3](=[O:21])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[N:5]/[O:6][CH3:7].S(Cl)([Cl:25])(=O)=O>ClCCl.O>[CH3:1][NH:2][C:3](=[O:21])/[C:4](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:16]=[CH:17][C:18]([Cl:25])=[CH:19][CH:20]=1)=[N:5]/[O:6][CH3:7]

참가 물질

5

반응물 2

HCID 24648Sulfuryl chlorideHCID 5483872(2E)-2-methoxyimino-N-methyl-2-(2-phenoxyphenyl)acetamide

생성물 1

HCID 19429863(2E)-2-[2-(4-chlorophenoxy)phenyl]-2-methoxyimino-N-methylacetamide수율 68.1%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

A solution of (E)-N-methyl-2-(2-phenoxyphenyl)-2-methoxyiminoacetamide (500 mg) in dichloromethane was cooled to 0° C., and sulfuryl chloride (285 mg) was dropwise added thereto. The resultant mixture was stirred at the same temperature for 2 hours, diluted with water and extracted with diethyl ether. The solvent was dried and removed, and the residue was subjected to HPLC with a mixture of hexane and ethyl acetate to give 382 mg of the objective compound.

후처리

  1. extractionextracted with diethyl ether
  2. customThe solvent was dried
  3. customremoved
  4. additionthe residue was subjected to HPLC with a mixture of hexane and ethyl acetate

출처 및 근거

ORD 기록
ord-e1b54a6892ab41e7b12785ca4b4efe79
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05371222

연결된 노트

불러오는 중…