Ethanol → Ethyl 5-benzyloxypentanoate

HRID 1491998노트

반응식

HRID 1491998 반응식
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16](O)[CH3:17].S(=O)(=O)(O)O>C(N(CC)CC)C>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 104205755-(Benzyloxy)pentanoic acid

생성물 1

HCID 18953758Ethyl 5-benzyloxypentanoate

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

A mixture of 61.1 g of 5-benzyloxypentanoic acid, 566 ml of ethanol and 10 ml of concentrated sulfuric acid is refluxed for 15 h. The mixture is cooled to room temperature, 10 ml of triethylamine are added and evaporated. The residue is diluted with 250 ml of ether and the solution is washed in water and brine dried (MgSO4) and evaporated. The residual oil is distilled to give ethyl 5-benzyloxypentanoate, b.p. 110°-113° C. (0.7 mm/Hg).

후처리

  1. temperatureis refluxed for 15 h
  2. customevaporated
  3. additionThe residue is diluted with 250 ml of ether
  4. washthe solution is washed in water
  5. dry with materialbrine dried (MgSO4)
  6. customevaporated
  7. distillationThe residual oil is distilled

출처 및 근거

ORD 기록
ord-6690fe47460a4ce08d4c3bc3fbdb9b2d
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05371096

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