3-[2-(Acetyloxy)ethyl]dihydro-2(3H)-furanone → 2H-Pyran-4-carboxylic acid, tetrahydro-, methyl ester
반응식
[C:1]([O:4][CH2:5][CH2:6][CH:7]1[CH2:11][CH2:10][O:9][C:8]1=[O:12])(=O)C>CO>[O:4]1[CH2:1][CH2:11][CH:7]([C:8]([O:9][CH3:10])=[O:12])[CH2:6][CH2:5]1참가 물질
3
실험 절차
A solution consisting of 57 wt % of 3-(2'-acetoxyethyl)-dihydro-2(3H)furanone and 43wt % of methanol was pumped into an evaporator (300° C.) at a rate of 170 g per hour, whence the vapors were passed together with 80 L/h of nitrogen over 560 g (950 mL) of Al2O3 (1.3 mm extrudates) at a reactor temperature of 250° C. using a trickle-bed method. The gaseous effluent was condensed in cold traps and analyzed by gas chromatography. 61 mol % of methyl tetrahydropyran-4-carboxylate was formed, plus 26 mol % of 3-(2'-methoxyethyl)-dihydro-2(3H)furanone and 5 mol % of 5-oxaspiro[2.4]heptan-4-one. The conversion of 3-(2'-acetoxyethyl)-dihydro-2(3H)furanone was 97%.
후처리
- customwas pumped into an evaporator (300° C.) at a rate of 170 g per hour, whence the vapors
- customwere passed together with 80 L/h of nitrogen over 560 g (950 mL) of Al2O3 (1.3 mm extrudates) at a reactor
- customtemperature of 250° C.
- customcondensed in cold traps
출처 및 근거
- ORD 기록
- ord-d4db3e89e4f442b1b0460d72cabe9dfe
- 출처 데이터셋
- uspto-grants-1994_12
- 특허 번호
- US05371246
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