Methanol → 2H-Pyran-4-carboxylic acid, tetrahydro-, methyl ester

HRID 1492027노트

반응식

HRID 1492027 반응식
[OH:1][CH2:2][CH2:3][CH:4]1[CH2:8][CH2:7][O:6][C:5]1=[O:9].[CH3:10]O>O>[O:1]1[CH2:2][CH2:3][CH:4]([C:5]([O:6][CH3:10])=[O:9])[CH2:8][CH2:7]1

참가 물질

4

반응물 2

HCID 887MethanolHCID 14047240Dihydro-3-(2-hydroxyethyl)-2(3H)-furanone

생성물 1

HCID 27735202H-Pyran-4-carboxylic acid, tetrahydro-, methyl ester

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution consisting of 45 wt % of 3-(2'-hydroxyethyl)-dihydro-2(3H)furanone, 45 wt % of methanol, and 10 wt % of water, was evaporated at a rate of 25 g per hour and the vapors were passed over 90 g of aluminum oxide catalyst (diameter 1.5 ram) in a tubular reactor at a temperature of 250° C. The gaseous effluent was condensed in cold traps and analyzed by gas chromatography. The experiment was carried out for a period of 60 h and the total amount of starting material used was 1500 g. 57 mol % of methyl tetrahydropyran-4-carboxylate was formed, plus 32 mol % of 3-(2'-methoxyethyl)-dihydro-2(3H)furanone and 4 mol % of 5-oxaspiro-[2.4 ]heptan-2-one, the conversion of 3-(2'-hydroxyethyl)-dihydro-2(3H)furanone being better than 97%.

후처리

  1. customwas evaporated at a rate of 25 g per hour
  2. customthe vapors were passed over 90 g of aluminum oxide catalyst (diameter 1.5 ram) in a tubular reactor at a temperature of 250° C
  3. customcondensed in cold traps

출처 및 근거

ORD 기록
ord-a7f20205c3f6416db3013270c73bf890
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05371246

반응 노트

불러오는 중…