Bromine → 6-Amino-5-bromo-1,2-dihydro-2,2-dimethyl-3-(4h)-quinoxalinone hydrobromide

HRID 1492134노트

반응식

HRID 1492134 반응식
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([CH3:13])([CH3:12])[C:6](=[O:14])[NH:5]2.[Br:15]Br>C(O)(=O)C>[BrH:15].[NH2:1][C:2]1[C:3]([Br:15])=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7]([CH3:12])([CH3:13])[C:6](=[O:14])[NH:5]2

참가 물질

4

반응물 2

HCID 24408BromineHCID 152257137-Amino-3,3-dimethyl-3,4-dihydroquinoxalin-2(1H)-one

생성물 1

HCID 199364056-Amino-5-bromo-1,2-dihydro-2,2-dimethyl-3-(4h)-quinoxalinone hydrobromide

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

A solution of 6-amino-1,2-dihydro-2,2-dimethyl-3-(4H) -quinoxalinone (250 mg, 1.31 mmol ) in glacial acetic acid (4 ml ) is cooled using a water bath. Bromine (210 mg, 1.31 mmol) in acetic acid (0.25 ml) is added dropwise over a 5 minute period. The mixture is stirred at room temperature for 4 hours and the resulting precipitate is collected by vacuum filtration. The title compound is obtained in pure form after drying in vacuo.

후처리

  1. filtrationthe resulting precipitate is collected by vacuum filtration

출처 및 근거

ORD 기록
ord-6bc8cc3a3cf447438669320059c53733
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05373010

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