Dimethylamine → 1,1-Dimethyl-2-(2-morpholinophenyl)guanidine

HRID 1492234노트

반응식

HRID 1492234 반응식
I.CS[C:4](=[NH:18])[NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.[CH3:19][NH:20][CH3:21]>C(O)C>[CH3:19][N:20]([CH3:21])[C:4]([NH2:18])=[N:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 178503978HCID 178503978, 화합물

생성물 1

HCID 98854071,1-Dimethyl-2-(2-morpholinophenyl)guanidine

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A mixture of 2-methyl-1-(2-morpholinophenyl)-2-thiopseudourea hydroiodide (1 g), dimethylamine (1 ml of a 33% solution in ethanol) and ethanol (2 ml) was kept at ambient temperature for 48 days. The mixture was then cooled in an ice bath. The resulting solid was separated by filtration, treated with dilute aqueous sodium hydroxide solution (5 ml) and the resulting mixture extracted with dichloromethane (2×50 ml). The extract was washed with brine, dried and the solvent removed by evaporation to give 1,1-dimethyl-2-(2-morpholinophenyl)guanidine (m.p. 143°-144° C.) which was recrystallised from hexane.

후처리

  1. temperatureThe mixture was then cooled in an ice bath
  2. customThe resulting solid was separated by filtration
  3. additiontreated with dilute aqueous sodium hydroxide solution (5 ml)
  4. extractionthe resulting mixture extracted with dichloromethane (2×50 ml)
  5. washThe extract was washed with brine
  6. customdried
  7. customthe solvent removed by evaporation

출처 및 근거

ORD 기록
ord-67e7f2b7501747a6851c57bdc98c64bd
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05373008

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