P-Cresol → Ethyl (p-tolyloxy)acetate

HRID 1492517

반응식

HRID 1492517 반응식
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.Br[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:8][C:3]1[CH:4]=[CH:5][C:6]([O:7][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:1][CH:2]=1

참가 물질

5

반응물 3

HCID 2879P-CresolHCID 7748Ethyl bromoacetateHCID 11430Potassium Carbonate

생성물 1

HCID 4047281Ethyl (p-tolyloxy)acetate수율 96.6%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

In 70 ml of acetone were suspended 5.00 g of p-cresol, 7.72 g of ethyl bromoacetate and 6.39 g of potassium carbonate, and the resulting mixture was refluxed for 12 hours. After the solvent was distilled off under reduced pressure, water was added to the mixture, followed by extraction with methylene chloride. The organic phase was washed with in aqueous 2N sodium hydroxide solution and then with saturated sodium chloride solution, which was then dried over magnesium sulfate. On evaporation of the solvent under reduced pressure, 8.67 g of ethyl 4-methylphenoxyacetate was produced.

후처리

  1. temperaturethe resulting mixture was refluxed for 12 hours
  2. distillationAfter the solvent was distilled off under reduced pressure, water
  3. additionwas added to the mixture
  4. extractionfollowed by extraction with methylene chloride
  5. washThe organic phase was washed with in aqueous 2N sodium hydroxide solution
  6. dry with materialwith saturated sodium chloride solution, which was then dried over magnesium sulfate
  7. customOn evaporation of the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-cdee900a5f4f409ca9c8d2c187058b2f
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05374641

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