Water → HCID 18950689, 화합물

HRID 1492553노트

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HRID 1492553 반응식
[NH2:1][CH:2]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)[CH2:3][CH2:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1.C(N(CC)CC)C.[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([S:35](Cl)(=[O:37])=[O:36])=[CH:31][CH:30]=1.O>ClCCl>[Cl:28][C:29]1[CH:34]=[CH:33][C:32]([S:35]([NH:1][CH:2]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[CH2:3][CH2:4][C:5]2[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=2)(=[O:37])=[O:36])=[CH:31][CH:30]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 73984-Chlorobenzenesulfonyl chlorideHCID 8471TriethylamineHCID 18950694HCID 18950694, 화합물

생성물 1

HCID 18950689HCID 18950689, 화합물수율 59%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 10 ml of the solution of 0.35 g of methyl 4-[3-amino-3-(3-pyridyl)propyl]benzoate in dichloromethane were added 0.22 ml of triethylamine and 0.33 g of p-chlorobenzene sulfonylchloride, and stirred at room temperature overnight. After completion of the reaction, the reaction mixture was poured into water, which was then extracted with dichloromethane, washed in saturated aqueous sodium chloride, and dried over magnesium sulfate. The residue was subjected to chromatography on a silica gel column, to obtain 0.34 g of methyl 4-[3-(4-chlorobenzenesulfonamido)-3-(3-pyridyl)propyl]benzoate. The spectrometric data supports the structure of [36] as follows.

후처리

  1. customAfter completion of the reaction
  2. extractionwas then extracted with dichloromethane
  3. washwashed in saturated aqueous sodium chloride
  4. dry with materialdried over magnesium sulfate

출처 및 근거

ORD 기록
ord-cfab2476c3834deba4b5587b8f4a7924
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05374641

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