HCID 54069555, 화합물 → HCID 18950751, 화합물

HRID 1492557노트

반응식

HRID 1492557 반응식
[O:1]=[C:2]([C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH:3]=[CH:4][C:5]1[CH:17]=[CH:16][C:8]([O:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:7][CH:6]=1>C(O)C.[H][H]>[O:1]=[C:2]([C:18]1[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=1)[CH2:3][CH2:4][C:5]1[CH:17]=[CH:16][C:8]([O:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:7][CH:6]=1

참가 물질

4

반응물 1

HCID 54069555HCID 54069555, 화합물

생성물 1

HCID 18950751HCID 18950751, 화합물수율 50.3%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 178418361HCID 178418361, 화합물용매

실험 절차

Ethyl 4-[3-oxo-3-(3-pyridyl)-1-propenyl]phenoxyacetate (3.85 g) and 1.15 g of 10% Pd--C were suspended in 300 ml of ethanol, and stirred in hydrogen atmosphere at ambient temperature and pressure for three hours. The reaction mixture was filtered, and the filtrate was evaporated under reduced pressure. The residue obtained was subjected to chromatography on a silica gel column, and from a fraction eluted with methylene chloride was obtained 1.95 g of ethyl 4-[3-oxo-3-(3-pyridyl)propyl]phenoxyacetate.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate was evaporated under reduced pressure
  3. customThe residue obtained
  4. washfrom a fraction eluted with methylene chloride

출처 및 근거

ORD 기록
ord-d2031f836e2f4531a4171913536e534b
출처 데이터셋
uspto-grants-1994_12
특허 번호
US05374641

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