Benzophenone oxime → Benzophenone

반응식

[C:1](=NO)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC(C1C=CC(SC2C=C(C3(OC)CC[O:36]CC3)C=C(F)C=2)=CC=1)C>>[C:1]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:36])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 11324Benzophenone oxime

HCID 193799314-{3-[4-(1-Chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran

생성물 1

HCID 3102Benzophenone수율 38%

반응 조건

온도: 60 °C

실험 절차

Using an analogous procedure to that described in Example 1 except that the reactants were heated to 60° C. for 2 hours, benzophenone oxime was reacted with 4-{3-[4-(1-chloroethyl)phenylthio]-5-fluorophenyl}-4-methoxytetrahydropyran to give benzophenone O-}4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-α-methylbenzyl}oxime as an oil in 38% yield.