2-Thiopheneacetyl chloride → 3-(Pyrrolidin-1-ylmethyl)-4-(2-thienylacetyl)morpholine hydrochloride

HRID 1493146노트

반응식

HRID 1493146 반응식
[N:1]1([CH2:6][CH:7]2[CH2:12][O:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[S:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[CH2:18][C:19]([Cl:21])=[O:20]>C(N(CC)CC)C>[ClH:21].[N:1]1([CH2:6][CH:7]2[CH2:12][O:11][CH2:10][CH2:9][N:8]2[C:19](=[O:20])[CH2:18][C:14]2[S:13][CH:17]=[CH:16][CH:15]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

4

반응물 2

HCID 1623622-Thiopheneacetyl chlorideHCID 189150613-(Pyrrolidin-1-ylmethyl)morpholine

생성물 1

HCID 189151853-(Pyrrolidin-1-ylmethyl)-4-(2-thienylacetyl)morpholine hydrochloride수율 76.6%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

The procedure described in Example 17 was repeated, but using 0.88 g of 3-(pyrrolidin-1-ylmethyl)morpholine, 2.0 ml of triethylamine and 0.45 g of 2-thienylacetyl chloride, to afford 0.71 g of the title compound, melting at 215° C. (dec.).

출처 및 근거

ORD 기록
ord-147a912508c240b0bb3b5f197c2dfa13
출처 데이터셋
uspto-grants-1991_06
특허 번호
US05021413

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